{ "@context": "https://schema.org", "@id": "https://aggr.aymericbeaumet.com/items/youtube-com-scienceetonnante/2025-05-16-l-arn-aux-origines-de-la-vie-sur-terre-le-monde-a-arn/#webpage", "@type": [ "WebPage", "ArchiveComponent" ], "articleBody": "Et si la vie sur Terre avait commencé par de l'ARN, avant l'apparition de l'ADN et des protéines ? C'est l'hypothèse dite du Monde à ARN.\n\nDétails et compléments dans le billet de blog qui accompagne la vidéo : https://scienceetonnante.com/blog/2025/05/16/lhypothese-du-monde-a-arn/\n\nMerci à Philippe Nghe de l'ESPCI pour avoir répondu à mes questions !\n\nLe serveur Discord de Science étonnante ➡️ https://discord.gg/GPamYjVYxA\n\n00:00 Introduction\\\n00:59 Les caractéristiques de la vie\\\n04:01 LUCA, notre ancêtre commun\\\n06:12 L'ARN\\\n09:08 Les biopolymères programmables\\\n13:28 L'ARN catalyseur : les ribozymes\\\n17:09 L'expérience de Miller-Urey\\\n19:27 Des nucléotides qui se forment spontanément ?\\\n22:20 L'autoréplication de l'ARN en question\n\nÉcrit et réalisé par David Louapre © Science étonnante\n\nAbonnez-vous : https://www.youtube.com/scienceetonnante\\\nMe soutenir sur Tipeee : http://www.tipeee.com/science-etonnante\\\nou Patreon : https://www.patreon.com/scienceetonnante\\\nMes livres : https://scienceetonnante.com/livres/\\\nFacebook : http://www.facebook.com/sciencetonnante\\\nTwitter : http://www.twitter.com/dlouapre\n\nBibliographie :\n\nFerris, J. P., et al. (1996). Synthesis of long prebiotic oligomers on mineral surfaces. Nature, 381(6577), 59–61. https://www.nature.com/articles/381059a0\\\nJohnston, W. K., et al. (2001). RNA-catalyzed RNA polymerization: Accurate and general RNA-templated primer extension. Science, 292(5520), 1319–1325. https://doi.org/10.1126/science.1060786\\\nDoudna, J. A., & Cech, T. R. (2002). The chemical repertoire of natural ribozymes. Nature, 418(6894), 222–228. https://doi.org/10.1038/418222a\\\nSeelig, B. (2008). An autocatalytic network for ribozyme self-construction. Nature Chemical Biology, 4(11), 654–655. https://doi.org/10.1038/nchembio1108-654\\\nLincoln, T. A., & Joyce, G. F. (2009). Self-sustained replication of an RNA enzyme. Science, 323(5918), 1229–1232. https://doi.org/10.1126/science.1167856\\\nPowner, M. W., et al. (2009). Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions. Nature, 459(7244), 239–242. https://doi.org/10.1038/nature08013\\\nMulkidjanian, A. Y., et al. (2012). Origin of first cells at terrestrial, anoxic geothermal fields. PNAS, 109(14), E821–E830. https://doi.org/10.1073/pnas.1117774109\\\nRobertson, M. P., & Joyce, G. F. (2012). The origins of the RNA world. Cold Spring Harbor Perspectives in Biology, 4(5), a003608. https://doi.org/10.1101/cshperspect.a003608\\\nCech, T. R. (2012). The RNA world in context. Cold Spring Harbor Perspectives in Biology, 4(7), a006742. https://doi.org/10.1101/cshperspect.a006742\\\nHiggs, P. G., & Lehman, N. (2015). The RNA world: Molecular cooperation at the origins of life. Nature Reviews Genetics, 16(1), 7–17. https://doi.org/10.1038/nrg3841\\\nHorning, D. P., & Joyce, G. F. (2016). Amplification of RNA by an RNA polymerase ribozyme. PNAS, 113(35), 9786–9791. https://doi.org/10.1073/pnas.1610103113\\\nMeinert, C., et al. (2016). Ribose and related sugars from ultraviolet irradiation of interstellar ice analogs. Science, 352(6282), 208–212. https://doi.org/10.1126/science.aad8137\\\nUsami, K., & Okamoto, A. (2017). Hydroxyapatite: Catalyst for a one-pot pentose formation. Organic & Biomolecular Chemistry, 15(42), 8888–8893. https://doi.org/10.1039/C7OB02051A\\\nKompanichenko, V. N. (2019). Exploring the Kamchatka geothermal region in the context of life’s beginning. Life, 9(2), 41. https://doi.org/10.3390/life9020041\\\nHud, N. V. (2019). RNA nucleosides built in one prebiotic pot. Science, 366(6461), 32–33. https://doi.org/10.1126/science.aaz1130\\\nBecker, S., et al. (2019). Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides. Science, 366(6461), 76–82. https://doi.org/10.1126/science.aax2747\\\nDamer, B., & Deamer, D. (2020). The hot spring hypothesis for an origin of life. Astrobiology, 20(4), 429–452. https://doi.org/10.1089/ast.2019.2045\\\nMuchowska, K. B., et al. (2020). Non-enzymatic metabolic reactions and life’s origins. Chemical Reviews, 120(15), 7708–7744. https://doi.org/10.1021/acs.chemrev.0c00191\\\nWołos, A., et al. (2020). Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry. Science, 369(6511), eaaw1955. https://doi.org/10.1126/science.aaw1955\\\nBlokhuis, A., Lacoste, D., & Nghe, P. (2020). Universal motifs and the diversity of autocatalytic systems. Proceedings of the National Academy of Sciences, 117(41), 25230–25236. https://doi.org/10.1073/pnas.2013527117\\\nYu, A. M., et al. (2021). Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates. Molecular Cell, 81(4), 870–883.e10. https://doi.org/10.1016/j.molcel.2020.12.017\\\nPavlinova, P., Lambert, C. N., Malaterre, C., & Nghe, P. (2022). Abiogenesis through gradual evolution of autocatalysis into template-based replication. FEBS Letters, 597(3), 344–379. https://doi.org/10.1002/1873-3468.14507\n", "authors": [ "ScienceEtonnante" ], "captured_at": "2026-09-08T10:17:10.166315+00:00", "category": "science", "content_html": "

Et si la vie sur Terre avait commencé par de l'ARN, avant l'apparition de l'ADN et des protéines ? C'est l'hypothèse dite du Monde à ARN.

\n

Détails et compléments dans le billet de blog qui accompagne la vidéo : https://scienceetonnante.com/blog/2025/05/16/lhypothese-du-monde-a-arn/

\n

Merci à Philippe Nghe de l'ESPCI pour avoir répondu à mes questions !

\n

Le serveur Discord de Science étonnante ➡️ https://discord.gg/GPamYjVYxA

\n

00:00 Introduction
\n00:59 Les caractéristiques de la vie
\n04:01 LUCA, notre ancêtre commun
\n06:12 L'ARN
\n09:08 Les biopolymères programmables
\n13:28 L'ARN catalyseur : les ribozymes
\n17:09 L'expérience de Miller-Urey
\n19:27 Des nucléotides qui se forment spontanément ?
\n22:20 L'autoréplication de l'ARN en question

\n

Écrit et réalisé par David Louapre © Science étonnante

\n

Abonnez-vous : https://www.youtube.com/scienceetonnante
\nMe soutenir sur Tipeee : http://www.tipeee.com/science-etonnante
\nou Patreon : https://www.patreon.com/scienceetonnante
\nMes livres : https://scienceetonnante.com/livres/
\nFacebook : http://www.facebook.com/sciencetonnante
\nTwitter : http://www.twitter.com/dlouapre

\n

Bibliographie :

\n

Ferris, J. P., et al. (1996). Synthesis of long prebiotic oligomers on mineral surfaces. Nature, 381(6577), 59–61. https://www.nature.com/articles/381059a0
\nJohnston, W. K., et al. (2001). RNA-catalyzed RNA polymerization: Accurate and general RNA-templated primer extension. Science, 292(5520), 1319–1325. https://doi.org/10.1126/science.1060786
\nDoudna, J. A., & Cech, T. R. (2002). The chemical repertoire of natural ribozymes. Nature, 418(6894), 222–228. https://doi.org/10.1038/418222a
\nSeelig, B. (2008). An autocatalytic network for ribozyme self-construction. Nature Chemical Biology, 4(11), 654–655. https://doi.org/10.1038/nchembio1108-654
\nLincoln, T. A., & Joyce, G. F. (2009). Self-sustained replication of an RNA enzyme. Science, 323(5918), 1229–1232. https://doi.org/10.1126/science.1167856
\nPowner, M. W., et al. (2009). Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions. Nature, 459(7244), 239–242. https://doi.org/10.1038/nature08013
\nMulkidjanian, A. Y., et al. (2012). Origin of first cells at terrestrial, anoxic geothermal fields. PNAS, 109(14), E821–E830. https://doi.org/10.1073/pnas.1117774109
\nRobertson, M. P., & Joyce, G. F. (2012). The origins of the RNA world. Cold Spring Harbor Perspectives in Biology, 4(5), a003608. https://doi.org/10.1101/cshperspect.a003608
\nCech, T. R. (2012). The RNA world in context. Cold Spring Harbor Perspectives in Biology, 4(7), a006742. https://doi.org/10.1101/cshperspect.a006742
\nHiggs, P. G., & Lehman, N. (2015). The RNA world: Molecular cooperation at the origins of life. Nature Reviews Genetics, 16(1), 7–17. https://doi.org/10.1038/nrg3841
\nHorning, D. P., & Joyce, G. F. (2016). Amplification of RNA by an RNA polymerase ribozyme. PNAS, 113(35), 9786–9791. https://doi.org/10.1073/pnas.1610103113
\nMeinert, C., et al. (2016). Ribose and related sugars from ultraviolet irradiation of interstellar ice analogs. Science, 352(6282), 208–212. https://doi.org/10.1126/science.aad8137
\nUsami, K., & Okamoto, A. (2017). Hydroxyapatite: Catalyst for a one-pot pentose formation. Organic & Biomolecular Chemistry, 15(42), 8888–8893. https://doi.org/10.1039/C7OB02051A
\nKompanichenko, V. N. (2019). Exploring the Kamchatka geothermal region in the context of life’s beginning. Life, 9(2), 41. https://doi.org/10.3390/life9020041
\nHud, N. V. (2019). RNA nucleosides built in one prebiotic pot. Science, 366(6461), 32–33. https://doi.org/10.1126/science.aaz1130
\nBecker, S., et al. (2019). Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides. Science, 366(6461), 76–82. https://doi.org/10.1126/science.aax2747
\nDamer, B., & Deamer, D. (2020). The hot spring hypothesis for an origin of life. Astrobiology, 20(4), 429–452. https://doi.org/10.1089/ast.2019.2045
\nMuchowska, K. B., et al. (2020). Non-enzymatic metabolic reactions and life’s origins. Chemical Reviews, 120(15), 7708–7744. https://doi.org/10.1021/acs.chemrev.0c00191
\nWołos, A., et al. (2020). Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry. Science, 369(6511), eaaw1955. https://doi.org/10.1126/science.aaw1955
\nBlokhuis, A., Lacoste, D., & Nghe, P. (2020). Universal motifs and the diversity of autocatalytic systems. Proceedings of the National Academy of Sciences, 117(41), 25230–25236. https://doi.org/10.1073/pnas.2013527117
\nYu, A. M., et al. (2021). Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates. Molecular Cell, 81(4), 870–883.e10. https://doi.org/10.1016/j.molcel.2020.12.017
\nPavlinova, P., Lambert, C. N., Malaterre, C., & Nghe, P. (2022). Abiogenesis through gradual evolution of autocatalysis into template-based replication. FEBS Letters, 597(3), 344–379. https://doi.org/10.1002/1873-3468.14507

\n", "content_markdown": "Et si la vie sur Terre avait commencé par de l'ARN, avant l'apparition de l'ADN et des protéines ? C'est l'hypothèse dite du Monde à ARN.\n\nDétails et compléments dans le billet de blog qui accompagne la vidéo : https://scienceetonnante.com/blog/2025/05/16/lhypothese-du-monde-a-arn/\n\nMerci à Philippe Nghe de l'ESPCI pour avoir répondu à mes questions !\n\nLe serveur Discord de Science étonnante ➡️ https://discord.gg/GPamYjVYxA\n\n00:00 Introduction\\\n00:59 Les caractéristiques de la vie\\\n04:01 LUCA, notre ancêtre commun\\\n06:12 L'ARN\\\n09:08 Les biopolymères programmables\\\n13:28 L'ARN catalyseur : les ribozymes\\\n17:09 L'expérience de Miller-Urey\\\n19:27 Des nucléotides qui se forment spontanément ?\\\n22:20 L'autoréplication de l'ARN en question\n\nÉcrit et réalisé par David Louapre © Science étonnante\n\nAbonnez-vous : https://www.youtube.com/scienceetonnante\\\nMe soutenir sur Tipeee : http://www.tipeee.com/science-etonnante\\\nou Patreon : https://www.patreon.com/scienceetonnante\\\nMes livres : https://scienceetonnante.com/livres/\\\nFacebook : http://www.facebook.com/sciencetonnante\\\nTwitter : http://www.twitter.com/dlouapre\n\nBibliographie :\n\nFerris, J. P., et al. (1996). Synthesis of long prebiotic oligomers on mineral surfaces. Nature, 381(6577), 59–61. https://www.nature.com/articles/381059a0\\\nJohnston, W. K., et al. (2001). RNA-catalyzed RNA polymerization: Accurate and general RNA-templated primer extension. Science, 292(5520), 1319–1325. https://doi.org/10.1126/science.1060786\\\nDoudna, J. A., & Cech, T. R. (2002). The chemical repertoire of natural ribozymes. Nature, 418(6894), 222–228. https://doi.org/10.1038/418222a\\\nSeelig, B. (2008). An autocatalytic network for ribozyme self-construction. Nature Chemical Biology, 4(11), 654–655. https://doi.org/10.1038/nchembio1108-654\\\nLincoln, T. A., & Joyce, G. F. (2009). Self-sustained replication of an RNA enzyme. Science, 323(5918), 1229–1232. https://doi.org/10.1126/science.1167856\\\nPowner, M. W., et al. (2009). Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions. Nature, 459(7244), 239–242. https://doi.org/10.1038/nature08013\\\nMulkidjanian, A. Y., et al. (2012). Origin of first cells at terrestrial, anoxic geothermal fields. PNAS, 109(14), E821–E830. https://doi.org/10.1073/pnas.1117774109\\\nRobertson, M. P., & Joyce, G. F. (2012). The origins of the RNA world. Cold Spring Harbor Perspectives in Biology, 4(5), a003608. https://doi.org/10.1101/cshperspect.a003608\\\nCech, T. R. (2012). The RNA world in context. Cold Spring Harbor Perspectives in Biology, 4(7), a006742. https://doi.org/10.1101/cshperspect.a006742\\\nHiggs, P. G., & Lehman, N. (2015). The RNA world: Molecular cooperation at the origins of life. Nature Reviews Genetics, 16(1), 7–17. https://doi.org/10.1038/nrg3841\\\nHorning, D. P., & Joyce, G. F. (2016). Amplification of RNA by an RNA polymerase ribozyme. PNAS, 113(35), 9786–9791. https://doi.org/10.1073/pnas.1610103113\\\nMeinert, C., et al. (2016). Ribose and related sugars from ultraviolet irradiation of interstellar ice analogs. Science, 352(6282), 208–212. https://doi.org/10.1126/science.aad8137\\\nUsami, K., & Okamoto, A. (2017). Hydroxyapatite: Catalyst for a one-pot pentose formation. Organic & Biomolecular Chemistry, 15(42), 8888–8893. https://doi.org/10.1039/C7OB02051A\\\nKompanichenko, V. N. (2019). Exploring the Kamchatka geothermal region in the context of life’s beginning. Life, 9(2), 41. https://doi.org/10.3390/life9020041\\\nHud, N. V. (2019). RNA nucleosides built in one prebiotic pot. Science, 366(6461), 32–33. https://doi.org/10.1126/science.aaz1130\\\nBecker, S., et al. (2019). Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides. Science, 366(6461), 76–82. https://doi.org/10.1126/science.aax2747\\\nDamer, B., & Deamer, D. (2020). The hot spring hypothesis for an origin of life. Astrobiology, 20(4), 429–452. https://doi.org/10.1089/ast.2019.2045\\\nMuchowska, K. B., et al. (2020). Non-enzymatic metabolic reactions and life’s origins. Chemical Reviews, 120(15), 7708–7744. https://doi.org/10.1021/acs.chemrev.0c00191\\\nWołos, A., et al. (2020). Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry. Science, 369(6511), eaaw1955. https://doi.org/10.1126/science.aaw1955\\\nBlokhuis, A., Lacoste, D., & Nghe, P. (2020). Universal motifs and the diversity of autocatalytic systems. Proceedings of the National Academy of Sciences, 117(41), 25230–25236. https://doi.org/10.1073/pnas.2013527117\\\nYu, A. M., et al. (2021). Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates. Molecular Cell, 81(4), 870–883.e10. https://doi.org/10.1016/j.molcel.2020.12.017\\\nPavlinova, P., Lambert, C. N., Malaterre, C., & Nghe, P. (2022). Abiogenesis through gradual evolution of autocatalysis into template-based replication. FEBS Letters, 597(3), 344–379. https://doi.org/10.1002/1873-3468.14507\n", "dateCreated": "2026-09-08T10:17:10.166315+00:00", "date_created": "2025-05-16T15:00:29+00:00", "date_modified": "2026-05-05T05:18:59+00:00", "date_published": "2025-05-16T15:00:29+00:00", "description": "Et si la vie sur Terre avait commencé par de l'ARN, avant l'apparition de l'ADN et des protéines ? C'est l'hypothèse dite du Monde à ARN. Détails et compléments dans le billet de blog qui accompagne la vidéo :…", "external_url": "https://www.youtube.com/watch?v=HR3fLfHu9U4", "git": { "commit": "ebb0941c5c06a2ab2377342d607535262a3e969e", "path": "items/youtube-com-scienceetonnante/2025/05/2025-05-16-l-arn-aux-origines-de-la-vie-sur-terre-le-monde-a-arn.md", "permalink": "https://github.com/aymericbeaumet/aggr-instance/blob/ebb0941c5c06a2ab2377342d607535262a3e969e/items/youtube-com-scienceetonnante/2025/05/2025-05-16-l-arn-aux-origines-de-la-vie-sur-terre-le-monde-a-arn.md" }, "id": "urn:aggr:item:34a06a52b8063fa755a53be9185340ea17f41656", "isBasedOn": { "@id": "https://www.youtube.com/watch?v=HR3fLfHu9U4" }, "mainEntity": { "@id": "https://www.youtube.com/watch?v=HR3fLfHu9U4", "@type": "CreativeWork", "archivedAt": { "@id": "https://aggr.aymericbeaumet.com/items/youtube-com-scienceetonnante/2025-05-16-l-arn-aux-origines-de-la-vie-sur-terre-le-monde-a-arn/#webpage" }, "author": [ { "@type": "Person", "name": "ScienceEtonnante" } ], "dateModified": "2026-05-05T05:18:59+00:00", "datePublished": "2025-05-16T15:00:29+00:00", "headline": "L'ARN aux Origines de la Vie sur Terre ? — Le Monde à ARN", "timeRequired": "PT4M", "url": "https://www.youtube.com/watch?v=HR3fLfHu9U4", "wordCount": 711 }, "name": "Archived snapshot: L'ARN aux Origines de la Vie sur Terre ? — Le Monde à ARN", "preview": null, "reading_minutes": 4, "replicated_at": null, "source": "youtube-com-scienceetonnante", "source_name": "ScienceEtonnante", "summary": "Et si la vie sur Terre avait commencé par de l'ARN, avant l'apparition de l'ADN et des protéines ? C'est l'hypothèse dite du Monde à ARN.\n\nDétails et compléments dans le billet de blog qui accompagne la vidéo : https://scienceetonnante.com/blog/2025/05/16/lhypothese-du-monde-a-arn/\n\nMerci à Philippe Nghe de l'ESPCI pour avoir répondu à mes questions ! \n\nLe serveur Discord de Science étonnante ➡️ https://discord.gg/GPamYjVYxA\n\n00:00 Introduction\n00:59 Les caractéristiques de la vie\n04:01 LUCA, notre ancêtre commun\n06:12 L'ARN\n09:08 Les biopolymères programmables\n13:28 L'ARN catalyseur : les ribozymes\n17:09 L'expérience de Miller-Urey\n19:27 Des nucléotides qui se forment spontanément ?\n22:20 L'autoréplication de l'ARN en question\n\nÉcrit et réalisé par David Louapre © Science étonnante\n\nAbonnez-vous : https://www.youtube.com/scienceetonnante\nMe soutenir sur Tipeee : http://www.tipeee.com/science-etonnante\nou Patreon : https://www.patreon.com/scienceetonnante\nMes livres : https://scienceetonnante.com/livres/\nFacebook : http://www.facebook.com/sciencetonnante\nTwitter : http://www.twitter.com/dlouapre\n\nBibliographie :\n\nFerris, J. P., et al. (1996). Synthesis of long prebiotic oligomers on mineral surfaces. Nature, 381(6577), 59–61. https://www.nature.com/articles/381059a0\nJohnston, W. K., et al. (2001). RNA-catalyzed RNA polymerization: Accurate and general RNA-templated primer extension. Science, 292(5520), 1319–1325. https://doi.org/10.1126/science.1060786\nDoudna, J. A., & Cech, T. R. (2002). The chemical repertoire of natural ribozymes. Nature, 418(6894), 222–228. https://doi.org/10.1038/418222a\nSeelig, B. (2008). An autocatalytic network for ribozyme self-construction. Nature Chemical Biology, 4(11), 654–655. https://doi.org/10.1038/nchembio1108-654\nLincoln, T. A., & Joyce, G. F. (2009). Self-sustained replication of an RNA enzyme. Science, 323(5918), 1229–1232. https://doi.org/10.1126/science.1167856\nPowner, M. W., et al. (2009). Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions. Nature, 459(7244), 239–242. https://doi.org/10.1038/nature08013\nMulkidjanian, A. Y., et al. (2012). Origin of first cells at terrestrial, anoxic geothermal fields. PNAS, 109(14), E821–E830. https://doi.org/10.1073/pnas.1117774109\nRobertson, M. P., & Joyce, G. F. (2012). The origins of the RNA world. Cold Spring Harbor Perspectives in Biology, 4(5), a003608. https://doi.org/10.1101/cshperspect.a003608\nCech, T. R. (2012). The RNA world in context. Cold Spring Harbor Perspectives in Biology, 4(7), a006742. https://doi.org/10.1101/cshperspect.a006742\nHiggs, P. G., & Lehman, N. (2015). The RNA world: Molecular cooperation at the origins of life. Nature Reviews Genetics, 16(1), 7–17. https://doi.org/10.1038/nrg3841\nHorning, D. P., & Joyce, G. F. (2016). Amplification of RNA by an RNA polymerase ribozyme. PNAS, 113(35), 9786–9791. https://doi.org/10.1073/pnas.1610103113\nMeinert, C., et al. (2016). Ribose and related sugars from ultraviolet irradiation of interstellar ice analogs. Science, 352(6282), 208–212. https://doi.org/10.1126/science.aad8137\nUsami, K., & Okamoto, A. (2017). Hydroxyapatite: Catalyst for a one-pot pentose formation. Organic & Biomolecular Chemistry, 15(42), 8888–8893. https://doi.org/10.1039/C7OB02051A\nKompanichenko, V. N. (2019). Exploring the Kamchatka geothermal region in the context of life’s beginning. Life, 9(2), 41. https://doi.org/10.3390/life9020041\nHud, N. V. (2019). RNA nucleosides built in one prebiotic pot. Science, 366(6461), 32–33. https://doi.org/10.1126/science.aaz1130\nBecker, S., et al. (2019). Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides. Science, 366(6461), 76–82. https://doi.org/10.1126/science.aax2747\nDamer, B., & Deamer, D. (2020). The hot spring hypothesis for an origin of life. Astrobiology, 20(4), 429–452. https://doi.org/10.1089/ast.2019.2045\nMuchowska, K. B., et al. (2020). Non-enzymatic metabolic reactions and life’s origins. Chemical Reviews, 120(15), 7708–7744. https://doi.org/10.1021/acs.chemrev.0c00191\nWołos, A., et al. (2020). Synthetic connectivity, emergence, and self-regeneration in the network of prebiotic chemistry. Science, 369(6511), eaaw1955. https://doi.org/10.1126/science.aaw1955\nBlokhuis, A., Lacoste, D., & Nghe, P. (2020). Universal motifs and the diversity of autocatalytic systems. Proceedings of the National Academy of Sciences, 117(41), 25230–25236. https://doi.org/10.1073/pnas.2013527117\nYu, A. M., et al. (2021). Computationally reconstructing cotranscriptional RNA folding from experimental data reveals rearrangement of non-native folding intermediates. Molecular Cell, 81(4), 870–883.e10. https://doi.org/10.1016/j.molcel.2020.12.017\nPavlinova, P., Lambert, C. N., Malaterre, C., & Nghe, P. (2022). Abiogenesis through gradual evolution of autocatalysis into template-based replication. 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